SPAG4 Antibody (PACO18428)
- SKU:
- PACO18428
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SPAG4 Antibody (PACO18428)
The SPAG4 Antibody (PAC018428) is a valuable tool for researchers studying SPAG4, a protein involved in sperm motility. This polyclonal antibody, produced using rabbits, is highly specific to human samples and is suitable for use in various research applications, including Western blotting. By binding to the SPAG4 protein, this antibody enables researchers to detect and analyze SPAG4 in different cell types, making it an ideal choice for research in reproductive biology and fertility studies.SPAG4, also known as sperm-associated antigen 4, plays a crucial role in sperm flagellum formation and motility.
Understanding the function of SPAG4 is essential for unraveling the mechanisms underlying male infertility and reproductive disorders. By investigating the expression and activity of SPAG4, researchers can gain insights into potential targets for therapeutic intervention in fertility-related issues.Overall, the SPAG4 Antibody is a valuable tool for researchers interested in unraveling the complexities of male fertility and reproductive biology. Its specificity and reliability make it a trusted resource for investigating the role of SPAG4 in sperm function and reproductive health.
| Antibody Name: | SPAG4 Antibody (PACO18428) |
| Antibody SKU: | PACO18428 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human SPAG4 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18428(SPAG4 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human seminoma tissue, Primary antibody: PACO18428(SPAG4 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18428(SPAG4 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. |
| Synonyms: | sperm associated antigen 4 |
| UniProt Protein Function: | Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail. |
| UniProt Protein Details: | |
| NCBI Summary: | The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q9NPE6 |
| NCBI GenInfo Identifier: | 11037055 |
| NCBI Gene ID: | 6676 |
| NCBI Accession: | NP_003107.1 |
| UniProt Secondary Accession: | Q9NPE6,O43648 |
| UniProt Related Accession: | Q9NPE6 |
| Molecular Weight: | 48,165 Da |
| NCBI Full Name: | sperm-associated antigen 4 protein isoform 1 |
| NCBI Synonym Full Names: | sperm associated antigen 4 |
| NCBI Official Symbol: | SPAG4Â Â |
| NCBI Official Synonym Symbols: | SUN4; CT127Â Â |
| NCBI Protein Information: | sperm-associated antigen 4 protein |
| UniProt Protein Name: | Sperm-associated antigen 4 protein |
| UniProt Synonym Protein Names: | Outer dense fiber-associated protein SPAG4; SUN domain-containing protein 4 |
| Protein Family: | Sperm-associated antigen 4 protein |
| UniProt Gene Name: | SPAG4Â Â |
| UniProt Entry Name: |
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