The SPACA1 Polyclonal Antibody (PAC040610) is a valuable tool for researchers studying SPACA1, a protein involved in sperm-egg fusion and fertilization. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By targeting the SPACA1 protein, researchers can analyze its expression and function in different cell types, making it ideal for investigations in reproductive biology and fertility research.SPACA1, also known as sperm acrosome-associated protein 1, is essential for the fusion of sperm with the egg during the fertilization process.
Understanding the role of SPACA1 is crucial for elucidating the mechanisms of fertilization and developing interventions for infertility treatments. Research on SPACA1 may also provide insights into contraception methods and reproductive health. By utilizing the PAC040610 antibody, researchers can advance their studies on SPACA1 and its implications in reproductive biology.
Antibody Name:
SPACA1 Antibody (PACO40610)
Antibody SKU:
PACO40610
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Sperm acrosome membrane-associated protein 1 protein (30-221AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO40610 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO40610 at dilution of 1:100.
Background:
May be involved in sperm-egg fusion.
Synonyms:
Sperm acrosome membrane-associated protein 1 (Sperm acrosomal membrane-associated protein 32), SPACA1, SAMP32
UniProt Protein Function:
SPACA1: May be involved in sperm-egg fusion.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 6q15Cellular Component: acrosomal membraneBiological Process: acrosome formation
UniProt Protein Details:
NCBI Summary:
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008]
