The SP6 Polyclonal Antibody (PAC035994) is a valuable tool for researchers studying SP6, a transcription factor essential for RNA polymerase II transcription. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blot analysis. By binding specifically to the SP6 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a crucial tool for studies in molecular biology and gene regulation.SP6 is a key player in orchestrating gene expression by promoting the transcription of target genes involved in various cellular processes.
Its role in regulating the expression of specific genes underscores its importance in developmental biology, stem cell research, and cancer biology. Research on SP6 can provide insights into the mechanisms governing gene regulation and offer potential therapeutic targets for diseases influenced by aberrant gene expression patterns. By utilizing the SP6 Polyclonal Antibody, researchers can delve deeper into the functions of SP6 and unravel its implications in different biological contexts, paving the way for advancements in understanding gene regulation and its impact on human health.
Antibody Name:
SP6 Antibody (PACO35994)
Antibody SKU:
PACO35994
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Transcription factor Sp6 protein (101-376AA)
SP6: Promotes cell proliferation. Belongs to the Sp1 C2H2-type zinc-finger protein family.
UniProt Protein Details:
Protein type:DNA-binding; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 17q21.32
NCBI Summary:
SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]
