The SP4 Polyclonal Antibody (CAB16431) is a valuable tool for researchers studying SP4, a transcription factor involved in the regulation of gene expression. This antibody, generated in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By binding specifically to the SP4 protein, researchers can effectively detect and analyze SP4 levels in various cell types, making it an ideal choice for studies in molecular biology and genetics.SP4 plays a crucial role in the transcriptional regulation of genes involved in cell proliferation, differentiation, and development.
Its importance in gene expression makes it a key player in various biological processes, including embryonic development, neuronal functioning, and cancer progression. By understanding the functions of SP4, researchers can gain insights into its role in disease pathogenesis and potentially identify new therapeutic targets for disorders such as cancer, neurological diseases, and developmental disorders.
Product Name:
SP4 Rabbit Polyclonal Antibody
SKU:
CAB16431
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 280-440 of human SP4 (NP_003103.2).
The protein encoded by this gene is a transcription factor that can bind to the GC promoter region of a variety of genes, including those of the photoreceptor signal transduction system. The encoded protein binds to the same sites in promoter CpG islands as does the transcription factor SP1, although its expression is much more restricted compared to that of SP1. This gene may be involved in bipolar disorder and schizophrenia.
Purification Method:
Affinity purification
Gene ID:
6671
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SP4 Rabbit pAb (CAB16431) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
