The SP140 Polyclonal Antibody (CAB17634) is a valuable tool for researchers studying the SP140 protein, which plays a crucial role in immune regulation and response. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the SP140 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in immunology, autoimmune disorders, and cancer research.
SP140 is known for its involvement in immune system function, particularly in regulating inflammatory responses and modulating immune cell activity. Its significance in immune homeostasis makes it a key target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the role of SP140 is essential for developing targeted therapies and treatment strategies that modulate immune function in these pathophysiological contexts.
Product Name:
SP140 Rabbit Polyclonal Antibody
SKU:
CAB17634
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SP140 (NP_001265380).
fibrillar center, mitochondrion, nucleus, PML body
Calculated MW:
98kDa
Observed MW:
98kDa
This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants.
Purification Method:
Affinity purification
Gene ID:
11262
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SP140 Rabbit pAb (CAB17634) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
