The SP1 Rabbit Monoclonal Antibody (CAB19649) is a cutting-edge research tool designed for studying the SP1 transcription factor, a key regulator of gene expression involved in various cellular processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot and immunohistochemistry applications.SP1 is known for its role in controlling the expression of genes involved in cell growth, differentiation, and apoptosis. Dysregulation of SP1 activity has been implicated in numerous diseases, including cancer, cardiovascular disorders, and neurological conditions.
By targeting SP1, researchers can gain insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic targets.The SP1 Rabbit Monoclonal Antibody (CAB19649) offers researchers a powerful tool for investigating the function of SP1 in various biological systems. Its high affinity and specificity ensure reliable and reproducible results, making it an essential reagent for studies in molecular biology, cancer research, and drug discovery. Unlock the potential of SP1 research with this innovative antibody from AssayGenie.
Product Name:
SP1 Rabbit Monoclonal Antibody
SKU:
CAB19649
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human SP1 (P08047).
Sequence:
TTLT PIAS AASI PAGT VTVN AAQL SSMP GLQT INLS ALGT SGIQ VHPI QGLP LAIA NAPG DHGA QLGL HGAG GDGI HDDT AGGE EGEN SPDA QPQA GRRT R
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6667
Clone Number:
ARC0128
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
CUT&Tag was performed using the CUT&Tag Assay Kit (pAG-Tn5) for Illumina(RK20265) from 10⁵ Hep G2 cells with 1 μg SP1 Rabbit mAb (CAB19649), along with a Goat Anti-Rabbit IgG(H+L). The CUT&Tag results indicate the enrichment pattern of SP1 in representative gene loci (TINF2), as shown in figure.
