SOX8 Antibody (PACO57984)
- SKU:
- PACO57984
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SOX8 Antibody (PACO57984)
The SOX8 Polyclonal Antibody (PAC057984) is a vital tool for researchers studying SOX8, a transcription factor involved in the regulation of gene expression and cell differentiation. This antibody, produced from rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot experiments. By targeting the SOX8 protein, this antibody enables precise detection and analysis in various cell types, making it an invaluable asset for investigations in developmental biology, stem cell research, and cancer biology.
SOX8, a member of the SOX family of transcription factors, plays a crucial role in controlling the expression of genes involved in cell fate determination and tissue development. Its involvement in key developmental processes makes it a promising target for research into stem cell differentiation, tissue regeneration, and pathogenesis of certain types of cancer. By understanding the functions of SOX8, researchers can potentially uncover novel therapeutic targets for various diseases and conditions.
| Antibody Name: | SOX8 Antibody (PACO57984) |
| Antibody SKU: | PACO57984 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Transcription factor SOX-8 protein (292-386AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: U87 whole cell lysate. All lanes: SOX8 antibody at 5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 48 kDa. Observed band size: 48 kDa. |
| Background: | May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity). |
| Synonyms: | Transcription factor SOX-8, SOX8 |
| UniProt Protein Function: | SOX8: May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: cytoplasm; nucleus Molecular Function:DNA binding; protein heterodimerization activity; transcription factor binding Biological Process: negative regulation of photoreceptor cell differentiation; transcription from RNA polymerase II promoter; fat cell differentiation; cell fate commitment; positive regulation of gliogenesis; in utero embryonic development; astrocyte fate commitment; positive regulation of transcription, DNA-dependent; male gonad development; cell maturation; signal transduction; Sertoli cell development; enteric nervous system development; peripheral nervous system development; osteoblast differentiation; retina development in camera-type eye; positive regulation of osteoblast proliferation; oligodendrocyte differentiation; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; neural crest cell migration; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). [provided by RefSeq, Jul 2008] |
| UniProt Code: | P57073 |
| NCBI GenInfo Identifier: | 10720294 |
| NCBI Gene ID: | 30812 |
| NCBI Accession: | P57073.1 |
| UniProt Secondary Accession: | P57073,P48436, Q9H6I2, P35713, |
| UniProt Related Accession: | P57073 |
| Molecular Weight: | 446 |
| NCBI Full Name: | Transcription factor SOX-8 |
| NCBI Synonym Full Names: | SRY (sex determining region Y)-box 8 |
| NCBI Official Symbol: | SOX8Â Â |
| NCBI Protein Information: | transcription factor SOX-8 |
| UniProt Protein Name: | Transcription factor SOX-8 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | SOX8Â Â |
| UniProt Entry Name: | SOX8_HUMAN |
| Antibodies |
| SOX8 Antibody (PACO12403) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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