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SOX8 Antibody (PACO12403)

SKU:
PACO12403
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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SOX8 Antibody (PACO12403)

The SOX8 Polyclonal Antibody (PACO12403) is a valuable tool for researchers studying the SOX8 protein, a transcription factor involved in various cellular processes, including embryonic development and stem cell proliferation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.SOX8 is known to play a crucial role in regulating gene expression and cell differentiation, making it a key player in developmental biology and cancer research. By targeting the SOX8 protein, researchers can investigate its function in different cell types and gain insights into its involvement in disease progression.

With its specificity and efficiency in detecting SOX8 protein, the PACO12403 antibody is an essential tool for scientists studying the molecular mechanisms underlying development, tissue regeneration, and pathogenesis. Its use can lead to a better understanding of SOX8's role in various biological processes and potentially pave the way for the development of targeted therapies for related disorders.

Antibody Name:SOX8 Antibody (PACO12403)
Antibody SKU:PACO12403
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Human SOX8
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:SRY (sex determining region Y)-box 8;SOX8;MGC24837 ;
UniProt Protein Function:SOX8: May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cytoplasm; nucleus

Molecular Function:DNA binding; protein heterodimerization activity; transcription factor binding

Biological Process: negative regulation of photoreceptor cell differentiation; transcription from RNA polymerase II promoter; fat cell differentiation; cell fate commitment; positive regulation of gliogenesis; in utero embryonic development; astrocyte fate commitment; positive regulation of transcription, DNA-dependent; male gonad development; cell maturation; signal transduction; Sertoli cell development; enteric nervous system development; peripheral nervous system development; osteoblast differentiation; retina development in camera-type eye; positive regulation of osteoblast proliferation; oligodendrocyte differentiation; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; neural crest cell migration; negative regulation of apoptosis

NCBI Summary:This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). [provided by RefSeq, Jul 2008]
UniProt Code:P57073
NCBI GenInfo Identifier:10720294
NCBI Gene ID:30812
NCBI Accession:P57073.1
UniProt Secondary Accession:P57073,P48436, Q9H6I2, P35713,
UniProt Related Accession:P57073
Molecular Weight:446
NCBI Full Name:Transcription factor SOX-8
NCBI Synonym Full Names:SRY (sex determining region Y)-box 8
NCBI Official Symbol:SOX8  
NCBI Protein Information:transcription factor SOX-8
UniProt Protein Name:Transcription factor SOX-8
Protein Family:Transcription factor
UniProt Gene Name:SOX8  
UniProt Entry Name:SOX8_HUMAN

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