The SOX6 Polyclonal Antibody (CAB7115) is a valuable tool for researchers studying the transcription factor SOX6, known for its involvement in various developmental processes, including chondrogenesis, neurogenesis, and cardiovascular development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.SOX6 plays a crucial role in the regulation of gene expression, particularly in the differentiation and maturation of specific cell types. By targeting the SOX6 protein, this antibody enables the detection and analysis of SOX6 expression in different cell types, making it ideal for studies in developmental biology, stem cell research, and tissue regeneration.
The importance of SOX6 in various biological processes makes it a key target for investigating diseases related to abnormal cell differentiation and development, such as skeletal disorders, neurological diseases, and cardiovascular conditions. By understanding the function and regulation of SOX6, researchers can gain insights that may lead to the development of potential therapeutic strategies in these areas.
Product Name:
SOX6 Rabbit Polyclonal Antibody
SKU:
CAB7115
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-74 of human SOX6 (NP_001139291.1).
Sequence:
MKGH GELQ GHER RMSS KQAT SPFA CAAD GEDA MTQD LTSR EKEE GSDQ HVAS HLPL HPIM HNKP HSEE LPTL VS
This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
55553
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SOX6 antibody (CAB7115) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
