The SOX2 Polyclonal Antibody (CAB11501) offered by Assay Genie is a powerful tool for researchers interested in studying the SOX2 protein, a transcription factor known to play a critical role in maintaining embryonic stem cell pluripotency, as well as in the development of various cancer types. This polyclonal antibody, raised in rabbits, is highly specific to human samples and is validated for use in Western blot and immunohistochemistry applications.SOX2, a key regulator of pluripotency and self-renewal in stem cells, is often overexpressed in cancers such as glioblastoma, lung cancer, and esophageal squamous cell carcinoma.
By detecting and analyzing the expression of SOX2 in various cell types, researchers can gain valuable insights into the molecular mechanisms underlying tumorigenesis and potentially identify new therapeutic targets.Given its importance in both development and disease, the SOX2 Polyclonal Antibody is a valuable tool for researchers working in stem cell biology, developmental biology, and cancer research. Understanding the role of SOX2 in these contexts can lead to the development of novel diagnostic and therapeutic strategies for a range of diseases.
Product Name:
SOX2 Rabbit Polyclonal Antibody
SKU:
CAB11501
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human SOX2 (NP_003097.1).
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Purification Method:
Affinity purification
Gene ID:
6657
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using SOX2 Rabbit pAb (CAB11501) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
