The SOSTDC1 Polyclonal Antibody (CAB16315) is a valuable tool for researchers studying SOSTDC1, a protein involved in bone development and regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting SOSTDC1 in human samples, making it ideal for use in Western blot experiments.SOSTDC1, also known as sclerostin domain-containing protein 1, is a secreted glycoprotein that acts as a potent antagonist of bone morphogenetic proteins (BMPs) and Wnt signaling pathways. By inhibiting these pathways, SOSTDC1 plays a crucial role in regulating bone formation and remodeling.
Dysregulation of SOSTDC1 has been implicated in various bone-related diseases, such as osteoporosis and osteosarcoma.By utilizing the SOSTDC1 Polyclonal Antibody, researchers can further investigate the function and role of SOSTDC1 in bone biology and pathology. Its versatility in various experimental techniques makes it a valuable tool for scientists working in the fields of orthopedics, endocrinology, and musculoskeletal research. Unlocking the mechanisms governed by SOSTDC1 can provide valuable insights for the development of novel therapeutics targeting bone disorders.
Product Name:
SOSTDC1 Rabbit Polyclonal Antibody
SKU:
CAB16315
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 115-206 of human SOSTDC1 (NP_056279.1).
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.
Purification Method:
Affinity purification
Gene ID:
25928
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SOSTDC1 Rabbit pAb (CAB16315) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
