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SOST Polyclonal Antibody (CAB24852)

SKU:
CAB24852
$155
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Description

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Product Name:SOST Polyclonal Antibody
SKU:CAB24852
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-213 of human SOST (NP_079513.1).
Sequence:QGWQ AFKN DATE IIPE LGEY PEPP PELE NNKT MNRA ENGG RPPH HPFE TKDV SEYS CREL HFTR YVTD GPCR SAKP VTEL VCSG QCGP ARLL PNAI GRGK WWRP SGPD FRCI PDRY RAQR VQLL CPGG EAPR ARKV RLVA SCKC KRLT RFHN QSEL KDFG TEAA RPQK GRKP RPRA RSAK ANQA ELEN AY
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:SOST; CDD; DAND6; SOST1; VBCH; sclerostin
Positive Sample:293T transfected with SOST protein
Conjugate:Unconjugated
Cellular Localization:Secreted, extracellular matrix, extracellular space.
Calculated MW:24kDa
Observed MW:27kDa

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Purification Method:Affinity purification
Gene ID:50964
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from wild type (WT) and 293T cells transfected with SOST using SOST Rabbit pAb(CAB24852) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.

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