The SOS2 Polyclonal Antibody (PACO22628) is a valuable tool for researchers studying the SOS2 protein, a key player in the RAS-RAF-MEK-ERK signaling pathway that regulates cell proliferation, survival, and differentiation. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting SOS2 in human samples, making it an ideal choice for Western blot applications.SOS2 is essential for transmitting extracellular signals to the nucleus, where they influence gene expression and cell behavior. Dysregulation of the RAS signaling pathway, in which SOS2 plays a crucial role, is commonly associated with cancer development and progression. By targeting SOS2 with this antibody, researchers can gain insights into the molecular mechanisms underlying cancer and potentially identify new therapeutic strategies.
In addition to its role in cancer, SOS2 is also involved in various other biological processes, including cell migration, adhesion, and differentiation. The ability to accurately detect and quantify SOS2 protein levels using this antibody is invaluable for advancing our understanding of these processes and their relevance to human health and disease. Whether investigating molecular pathways in cancer biology or studying normal cellular functions, the SOS2 Polyclonal Antibody is an essential tool for researchers seeking to unravel the complexities of cell signaling.
Antibody Name:
SOS2 Antibody (PACO22628)
Antibody SKU:
PACO22628
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human SOS2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from K562 cells and Jurkat cells, using SOS2 antibody.
Background:
Promotes the exchange of Ras-bound GDP by GTP By similarity.
Synonyms:
Son of sevenless homolog 2; SOS-2; SOS2;
UniProt Protein Function:
SOS2: a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2.Protein type: Motility/polarity/chemotaxis; GEFs, Ras; GEFs; Adaptor/scaffoldChromosomal Location of Human Ortholog: 14q21Cellular Component: cytosolMolecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; DNA binding; protein heterodimerization activityBiological Process: positive regulation of small GTPase mediated signal transduction; axon guidance; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction
