The SOS2 Polyclonal Antibody (PACO05105) is a valuable tool for researchers studying the SOS2 protein, a key regulator of the Ras signaling pathway involved in cell growth and proliferation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the SOS2 protein, researchers can assess its expression and activity in various cell types, making it an essential component for studies in cancer biology and signal transduction research.SOS2, a guanine nucleotide exchange factor, plays a crucial role in activating Ras proteins, which are important for cell survival and growth. Dysregulation of the Ras signaling pathway is commonly associated with cancer development and progression, making SOS2 an attractive target for therapeutic interventions.
By elucidating the function of SOS2, researchers can gain insights into potential treatment strategies for cancer and other diseases driven by aberrant Ras signaling. Overall, the SOS2 Polyclonal Antibody is a reliable tool for investigating the role of SOS2 in cellular signaling pathways and its implications for disease development. Its specificity and sensitivity make it a valuable asset for researchers aiming to unravel the complexities of cancer biology and identify novel therapeutic targets.
Antibody Name:
SOS2 Antibody (PACO05105)
Antibody SKU:
PACO05105
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human Sos 2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SOS2; Son of sevenless homolog 2; SOS-2
UniProt Protein Function:
SOS2: a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2.Protein type: Motility/polarity/chemotaxis; GEFs, Ras; GEFs; Adaptor/scaffoldChromosomal Location of Human Ortholog: 14q21Cellular Component: cytosolMolecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; DNA binding; protein heterodimerization activityBiological Process: positive regulation of small GTPase mediated signal transduction; axon guidance; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction