The SOS1 Polyclonal Antibody (CAB3272) is a valuable tool for researchers studying the SOS1 protein, a key regulator of intracellular signaling pathways involved in cell growth and proliferation. This antibody is raised in rabbits and has been validated for use in various applications, including Western blot and immunohistochemistry.SOS1 is a guanine nucleotide exchange factor (GEF) that activates Ras, a protein involved in cell proliferation and survival. Dysregulation of the SOS1-Ras pathway has been implicated in numerous diseases, including cancer and developmental disorders. By targeting SOS1 with this specific antibody, researchers can investigate its role in these conditions and potentially identify new therapeutic targets.
The high reactivity of the SOS1 Polyclonal Antibody with human samples makes it a valuable tool for studying the expression and localization of SOS1 in different cell types and tissues. Its use in immunohistochemistry allows for detailed analysis of SOS1 protein levels within cells, providing valuable insights into its function and potential as a therapeutic target.Overall, the SOS1 Polyclonal Antibody is a reliable and versatile reagent for researchers interested in exploring the role of SOS1 in cell signaling pathways and its implications for human health and disease.
Product Name:
SOS1 Rabbit Polyclonal Antibody
SKU:
CAB3272
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1034-1333 of human SOS1 (NP_005624.2).
cytoplasm, cytosol, plasma membrane, postsynaptic density
Calculated MW:
152kDa
Observed MW:
175kDa/200kDa
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4.
Purification Method:
Affinity purification
Gene ID:
6654
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SOS1 antibody (CAB3272) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
