The Sorting Nexin 1 Polyclonal Antibody (CAB8625) is a valuable tool for researchers studying Sorting Nexin 1, a protein involved in intracellular trafficking and endosomal sorting. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the Sorting Nexin 1 protein, this antibody allows for the detection and analysis of Sorting Nexin 1 in various cell types, making it ideal for investigations in cell biology and membrane trafficking research.
Sorting Nexin 1 is known for its role in determining the fate of cargo proteins within the endosomal network, making it crucial for understanding intracellular trafficking pathways. Dysfunction in Sorting Nexin 1 has been linked to various diseases, including neurodegenerative disorders and endosomal trafficking defects. As such, the Sorting Nexin 1 Polyclonal Antibody is a valuable tool for unlocking the molecular mechanisms underlying these conditions and developing targeted therapies to counteract them.
Product Name:
SNX1 Rabbit Polyclonal Antibody
SKU:
CAB8625
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human SNX1 (NP_003090.2).
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
6642
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SNX1 antibody (CAB8625) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
