The Sortilin Polyclonal Antibody (CAB7926) is a valuable tool for researchers studying Sortilin, a protein involved in intracellular trafficking and regulation of neurotrophic signaling. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot and immunohistochemistry applications. By binding to Sortilin, the antibody enables accurate detection and analysis of this protein in various cell types, making it ideal for studies in neuroscience, neurodegenerative diseases, and cellular transport processes.Sortilin, also known as neurotensin receptor 3, is integral in mediating the transport and sorting of proteins within cells, as well as modulating neurotrophic signals that are crucial for neuronal survival and function.
Dysregulation of Sortilin has been implicated in various neurodegenerative disorders, making it a potential therapeutic target for conditions such as Alzheimer's disease and Parkinson's disease. Understanding the role of Sortilin in cellular processes and neurotrophic signaling pathways is essential for advancing research and developing targeted therapies for these debilitating conditions.
Product Name:
SORT1 Rabbit Polyclonal Antibody
SKU:
CAB7926
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 785-823 of human SORT1 (NP_002950.3).
This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6272
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SORT1 antibody (CAB7926) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
