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Sort1 Antibody (PACO30088)

SKU:
PACO30088
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407
Frequently bought together:

Description

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Sort1 Antibody (PACO30088)

The Sortilin 1 (SORT1) Polyclonal Antibody (PACO30088) is a valuable tool for researchers studying SORT1, a cell surface receptor involved in a variety of cellular processes. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to SORT1, this antibody allows for the accurate detection and analysis of SORT1 expression in different cell types, making it an ideal choice for studies focused on neuroscience, cardiovascular diseases, and metabolic disorders.

SORT1, also known as sortilin-related receptor with A-type repeats (SORLA), plays a crucial role in protein trafficking and cellular signaling pathways, making it a key player in various physiological and pathological conditions. Dysregulation of SORT1 has been linked to neurodegenerative diseases, atherosclerosis, and diabetes, highlighting its importance as a potential therapeutic target. Studying the function of SORT1 is essential for advancing our understanding of these diseases and developing targeted therapies to address them.

Antibody Name:Sort1 Antibody (PACO30088)
Antibody SKU:PACO30088
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Rat
Immunogen:Recombinant Rat Sortilin protein (610-754AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
Synonyms:Sortilin (Glycoprotein 110) (Gp110) (Neurotensin receptor 3) (NTR3), Sort1
UniProt Protein Function:SORT1: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. A common polymorphism located in a non-coding region between CELSR2 and PSRC1 alters a CEBP transcription factor binding site and is responsible for changes in hepatic expression of SORT1. Altered SORT1 expression in liver affects low density lipoprotein cholesterol levels in plasma and is associated with susceptibility to myocardial infarction. Belongs to the VPS10-related sortilin family. SORT1 subfamily.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 2q34Cellular Component: cell soma; cell surface; clathrin-coated vesicle; coated pit; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; dendrite; early endosome; Golgi apparatus; integral to membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network transport vesicleMolecular Function: enzyme binding; nerve growth factor binding; nerve growth factor receptor activity; neurotensin receptor activity, G-protein coupled; neurotensin receptor activity, non-G-protein coupledBiological Process: endocytosis; endosome to lysosome transport; endosome transport via multivesicular body sorting pathway; G-protein coupled receptor protein signaling pathway; glucose import; Golgi to endosome transport; induction of apoptosis via death domain receptors; myotube differentiation; negative regulation of fat cell differentiation; negative regulation of lipoprotein lipase activity; nerve growth factor receptor signaling pathway; neuropeptide signaling pathway; plasma membrane to endosome transport; regulation of gene expression; response to insulin stimulus; vesicle organization and biogenesis
UniProt Protein Details:
NCBI Summary:may be involved in sorting lumenal proteins in the trans-Golgi [RGD, Feb 2006]
UniProt Code:O54861
NCBI GenInfo Identifier:209954677
NCBI Gene ID:83576
NCBI Accession:NP_113955.1
UniProt Secondary Accession:O54861,O35389
UniProt Related Accession:O54861
Molecular Weight:32.5kD
NCBI Full Name:sortilin
NCBI Synonym Full Names:sortilin 1
NCBI Official Symbol:Sort1  
NCBI Official Synonym Symbols:Nt3; Nts3  
NCBI Protein Information:sortilin
UniProt Protein Name:Sortilin
UniProt Synonym Protein Names:Glycoprotein 110; Gp110; Neurotensin receptor 3; NTR3
Protein Family:Sortilin
UniProt Gene Name:Sort1  
UniProt Entry Name:

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