The SorLA Polyclonal Antibody (CAB13047) is a vital tool for researchers studying SorLA (Sortilin-related receptor), a protein involved in various cellular processes including endocytosis, sorting, and trafficking. This antibody, generated in rabbit hosts, demonstrates high specificity and sensitivity for SorLA in human samples, making it ideal for Western blot applications.SorLA, a member of the VPS10P domain receptor family, has been implicated in Alzheimer's disease, cardiovascular disorders, and lipid metabolism.
Its versatile functions in cellular pathways make it a promising target for investigating disease mechanisms and potential therapeutic interventions. By utilizing the SorLA Polyclonal Antibody, researchers can elucidate the role of SorLA in health and disease, paving the way for novel discoveries and advancements in biomedical research.
Product Name:
SORL1 Rabbit Polyclonal Antibody
SKU:
CAB13047
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2065-2214 of human SORL1 (NP_003096.1).
Endosome, Golgi apparatus, Membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
248kDa
Observed MW:
260kDa
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease.
Purification Method:
Affinity purification
Gene ID:
6653
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from SH-SY5Y cells, using SORL1 Rabbit pAb (CAB13047) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
