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SORCS1 Antibody (PACO54542)

SKU:
PACO54542
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • SORCS1 Antibody PACO54542
  • SORCS1 Antibody PACO54542
  • SORCS1 Antibody PACO54542
€359

Description

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SORCS1 Antibody (PACO54542)

The SORCS1 Polyclonal Antibody (PACO54542) is a valuable tool for researchers studying SORCS1, a protein involved in various cellular functions including intracellular trafficking and signaling pathways. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the SORCS1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in neuroscience, developmental biology, and metabolism research.

SORCS1, a member of the VPS10P domain receptor family, is known to be involved in processes such as endocytosis, vesicular trafficking, and protein sorting. Its diverse functions make it a key player in various physiological and pathological conditions, including neurodegenerative disorders, metabolic diseases, and cancer. Investigating the role of SORCS1 can provide valuable insights into these complex diseases and potentially lead to the development of novel therapeutic strategies targeting this protein.

Antibody Name:SORCS1 Antibody (PACO54542)
Antibody SKU:PACO54542
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human VPS10 domain-containing receptor SorCS1 protein (34-175AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot. Positive WB detected in: K562 whole cell lysate. All lanes: SORCS1 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 130, 134, 132 kDa. Observed band size: 130 kDa.
Product ImageImmunofluorescence staining of MCF-7 cells with PACO54542 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Product ImageImmunohistochemistry of paraffin-embedded human breast cancer using PACO54542 at dilution of 1:100.
Background:membrane, neuropeptide receptor activity, neuropeptide signaling pathway
Synonyms:VPS10 domain-containing receptor SorCS1 (hSorCS), SORCS1, SORCS
UniProt Protein Function:SORCS1: one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 10q23-q25

Cellular Component: membrane; integral to membrane

Molecular Function:protein binding; neuropeptide receptor activity

Biological Process: neuropeptide signaling pathway

NCBI Summary:This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WY21
NCBI GenInfo Identifier:61743975
NCBI Gene ID:114815
NCBI Accession:NP_001013049.1
UniProt Secondary Accession:Q8WY21,Q59GG7, Q5JVT7, Q5JVT8, Q5VY14, Q86WQ1, Q86WQ2 Q9H1Y1, Q9H1Y2, A2RRF4,
UniProt Related Accession:Q8WY21
Molecular Weight:129,635 Da
NCBI Full Name:VPS10 domain-containing receptor SorCS1 isoform b
NCBI Synonym Full Names:sortilin-related VPS10 domain containing receptor 1
NCBI Official Symbol:SORCS1  
NCBI Official Synonym Symbols:hSorCS  
NCBI Protein Information:VPS10 domain-containing receptor SorCS1; VPS10 domain receptor protein SORCS 1
UniProt Protein Name:VPS10 domain-containing receptor SorCS1
Protein Family:VPS10 domain-containing receptor
UniProt Gene Name:SORCS1  
UniProt Entry Name:SORC1_HUMAN
ELISA Kits
Human SorCS1 ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
Recommended Products
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

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