The Sorcin Polyclonal Antibody (CAB6751) is a valuable tool for research involving Sorcin, a calcium-binding protein known for its role in multidrug resistance and cellular signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot and immunohistochemistry applications.Sorcin, also known as Soluble Resistance-Related Calcium Binding Protein, is involved in regulating calcium homeostasis and has been implicated in drug resistance in cancer cells. Its expression has been linked to various cancer types, making it a promising target for cancer research and drug development.
By targeting Sorcin, researchers can gain insights into mechanisms of drug resistance and potentially develop more effective treatment strategies.The Sorcin Polyclonal Antibody enables the detection and analysis of Sorcin protein in a variety of cell types, making it a versatile tool for studying its functions in cancer biology and beyond. Understanding the role of Sorcin in multidrug resistance and signaling pathways is essential for advancing our knowledge of cancer biology and developing targeted therapies for resistant tumors.
Product Name:
SRI Rabbit Polyclonal Antibody
SKU:
CAB6751
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human SRI (NP_003121.1).
This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene.
Purification Method:
Affinity purification
Gene ID:
6717
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type(WT) and SRI knockout (KO) HeLa(KO) cells, using [KO Validated] SRI Rabbit pAb (CAB6751) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
