The Sorbitol Dehydrogenase Monoclonal Antibody is a specialized tool for studying the enzyme sorbitol dehydrogenase, which plays a key role in the metabolism of sorbitol. This monoclonal antibody is specifically designed for use in research related to sorbitol dehydrogenase, a crucial enzyme in the sorbitol pathway.Raised in mice, this antibody is highly specific and sensitive, making it an ideal choice for detecting and analyzing sorbitol dehydrogenase in various biological samples. It has been validated for use in Western blot applications, providing reliable and reproducible results.Sorbitol dehydrogenase is involved in the conversion of sorbitol to fructose, a process that is essential for normal metabolic function.
Dysregulation of this enzyme has been implicated in various metabolic disorders, making it a valuable target for research in the fields of metabolism, diabetes, and liver disease.By using the Sorbitol Dehydrogenase Monoclonal Antibody, researchers can gain valuable insights into the function and regulation of sorbitol dehydrogenase, paving the way for a better understanding of its role in health and disease. Whether studying metabolic pathways or investigating potential therapeutic targets, this antibody is a valuable tool for advancing scientific research.
Product Name:
Sorbitol Dehydrogenase Monoclonal Antibody
SKU:
CAB21952
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Sorbitol Dehydrogenase (NP_003095.2).
Sequence:
REND EFCK MGRY NLSP SIFF CATP PDDG NLCR FYKH NAAF CYKL PDNV TFEE GALI EPLS VGIH ACRR GGVT LGHK VLVC GAGP IGMV TLLV AKAM GAAQ V
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.
Purification Method:
Affinity purification
Gene ID:
6652
Clone Number:
ARC53945
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Sorbitol Dehydrogenase antibody (CAB21952) at1:20000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
