The SOD3 Polyclonal Antibody (CAB6984) is a valuable tool for researchers studying Superoxide Dismutase 3 (SOD3), a member of the superoxide dismutase enzyme family that plays a crucial role in antioxidant defense mechanisms. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples and has been validated for use in Western blot applications.SOD3 is an extracellular antioxidant enzyme that helps to protect cells from oxidative stress by converting superoxide radicals into oxygen and hydrogen peroxide. Its function is particularly important in tissues exposed to high levels of oxidative stress, such as the lungs and blood vessels.
Research into SOD3 has implications for understanding and potentially treating conditions related to oxidative damage, such as cardiovascular diseases, neurodegenerative disorders, and aging.By utilizing the SOD3 Polyclonal Antibody, researchers can accurately detect and analyze SOD3 protein expression in various cell types, providing insights into its role in health and disease. This antibody is a valuable tool for investigations in the fields of biochemistry, molecular biology, and physiology, where the study of antioxidant enzymes and oxidative stress pathways is of great importance.
Product Name:
SOD3 Rabbit Polyclonal Antibody
SKU:
CAB6984
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 19-160 of human SOD3 (NP_003093.2).
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk.
Purification Method:
Affinity purification
Gene ID:
6649
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SOD3 Rabbit pAb (CAB6984) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
