The SOD2 Polyclonal Antibody (CAB1340) is specifically designed for research involving Superoxide Dismutase 2 (SOD2), an important enzyme involved in antioxidant defense and mitochondrial function. This antibody, produced in rabbits, exhibits high reactivity with human, mouse, and rat samples, making it suitable for various experimental applications, including Western blot analysis.SOD2 is a critical enzyme that plays a key role in the regulation of reactive oxygen species (ROS) levels within cells, protecting them from oxidative damage and maintaining cellular homeostasis. Dysregulation of SOD2 has been implicated in a variety of diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer.
Therefore, studying the expression and activity of SOD2 using the CAB1340 antibody can provide valuable insights into the role of this enzyme in health and disease.Researchers in the fields of biochemistry, cell biology, and molecular biology can benefit from the use of the SOD2 Polyclonal Antibody (CAB1340) to investigate the function of SOD2 in different cellular contexts and to explore potential therapeutic strategies targeting this enzyme in various pathological conditions. This antibody offers a reliable tool for the detection and analysis of SOD2 protein levels, contributing to a better understanding of oxidative stress mechanisms and redox signaling pathways in biological systems.
Product Name:
[KO Validated] SOD2 Rabbit Polyclonal Antibody
SKU:
CAB1340
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-222 of human SOD2 (NP_000627.2).
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1.
Purification Method:
Affinity purification
Gene ID:
6648
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] SOD2 Rabbit pAb (CAB1340) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
