The SOD1 Polyclonal Antibody (CAB0274) is a valuable tool for researchers studying superoxide dismutase 1 (SOD1), an important enzyme involved in protecting cells from oxidative stress. This antibody, generated in rabbits, is highly specific to human SOD1 and has been validated for use in Western blot applications. By binding to the SOD1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it a versatile option for studies in biology and disease research.SOD1 is known for its role in breaking down superoxide radicals, which can cause damage to cells if not properly neutralized.
Dysregulation of SOD1 has been implicated in a range of diseases, including neurodegenerative disorders like ALS. By studying SOD1 and its function, researchers can gain insights into the mechanisms of oxidative stress and potentially develop new therapeutic strategies for treating diseases associated with oxidative damage.Overall, the SOD1 Polyclonal Antibody offers a reliable tool for investigating the role of SOD1 in cellular health and disease. Its specificity and sensitivity make it a valuable asset for understanding the complex interplay between oxidative stress and disease pathology.
Product Name:
SOD1 Rabbit Polyclonal Antibody
SKU:
CAB0274
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2-154 of human SOD1 (NP_000445.1).
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
Purification Method:
Affinity purification
Gene ID:
6647
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using SOD1 Rabbit pAb (CAB0274) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
