SOD1 Rabbit Polyclonal Antibody (CAB0274)
- SKU:
- CAB0274
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | SOD1 Rabbit Polyclonal Antibody |
SKU: | CAB0274 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2-154 of human SOD1 (NP_000445.1). |
Sequence: | ATKA VCVL KGDG PVQG IINF EQKE SNGP VKVW GSIK GLTE GLHG FHVH EFGD NTAG CTSA GPHF NPLS RKHG GPKD EERH VGDL GNVT ADKD GVAD VSIE DSVI SLSG DHCI IGRT LVVH EKAD DLGK GGNE ESTK TGNA GSRL ACGV IGIA Q |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | ALS; SOD; ALS1; IPOA; STAHP; hSod1; HEL-S-44; homodimer; SOD1 |
Positive Sample: | HeLa,293T,MCF7,Mouse liver,Mouse brain,Rat lung,Rat liver,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 16kDa |
Observed MW: | 16-18kDa |
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
Purification Method: | Affinity purification |
Gene ID: | 6647 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |