The SOD1 Monoclonal Antibody (CAB21211) is a highly specific antibody designed for research involving superoxide dismutase 1 (SOD1), an essential enzyme involved in antioxidant defense mechanisms. The antibody, produced through monoclonal antibody technology, is highly sensitive and specific for detecting SOD1 in various samples, particularly in Western blot applications. It binds specifically to the SOD1 protein, enabling precise detection and analysis in different cell types.SOD1 is a crucial enzyme that catalyzes the dismutation of superoxide radicals, playing a vital role in protecting cells from oxidative stress and damage.
Dysregulation of SOD1 has been implicated in various diseases, including neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS). Research on SOD1 is essential for understanding its role in oxidative stress-related diseases and developing therapeutic strategies targeting this enzyme.Overall, the SOD1 Monoclonal Antibody (CAB21211) is a valuable tool for researchers in the fields of oxidative stress, neurodegenerative diseases, and antioxidant defense mechanisms. Its high specificity and sensitivity make it an ideal choice for studying SOD1 expression and function in various experimental settings.
Product Name:
SOD1 Monoclonal Antibody
SKU:
CAB21211
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2-154 of human SOD1 (NP_000445.1).
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
Purification Method:
Affinity purification
Gene ID:
6647
Clone Number:
ARC51786
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma using SOD1 Rabbit mAb (CAB21211) at dilution of 1:1600(40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
