null

Sod1 Antibody (PACO30072)

SKU:
PACO30072
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

Sod1 Antibody (PACO30072)

The SOD1 Polyclonal Antibody (PACO30072) is a valuable tool for researchers interested in studying Superoxide Dismutase 1 (SOD1), a key enzyme involved in antioxidant defense. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications.SOD1 plays a crucial role in neutralizing harmful superoxide radicals, thereby protecting cells from oxidative stress and damage. Dysregulation of SOD1 function has been implicated in various diseases, including neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS).

By targeting SOD1 with this antibody, researchers can investigate its expression levels and localization in different cell types, shedding light on its physiological and pathological roles.By utilizing the SOD1 Polyclonal Antibody (PACO30072), researchers can gain valuable insights into the mechanisms underlying oxidative stress-related diseases and potentially identify new therapeutic targets for intervention. This antibody is a valuable tool for studies in fields such as neurobiology, aging research, and metabolic disorders.

Antibody Name:Sod1 Antibody (PACO30072)
Antibody SKU:PACO30072
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Mouse
Immunogen:Recombinant Mouse Superoxide dismutase [Cu-Zn] protein (2-154AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Synonyms:Superoxide dismutase [Cu-Zn] (EC 1.15.1.1), Sod1
UniProt Protein Function:SOD1: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not. Belongs to the Cu-Zn superoxide dismutase family.
UniProt Protein Details:

Protein type:EC 1.15.1.1; Apoptosis; Nuclear receptor co-regulator; Oxidoreductase; Mitochondrial

Cellular Component: cell soma; cytoplasm; cytoplasmic vesicle; cytosol; dendrite cytoplasm; extracellular matrix; extracellular region; extracellular space; lysosome; mitochondrial intermembrane space; mitochondrion; myelin sheath; neuron projection; nucleoplasm; nucleus; peroxisome; plasma membrane; protein complex; secretory granule

Molecular Function:antioxidant activity; chaperone binding; copper ion binding; enzyme binding; identical protein binding; metal ion binding; oxidoreductase activity; protein binding; protein phosphatase 2B binding; Rac GTPase binding; superoxide dismutase activity; zinc ion binding

Biological Process: activation of MAPK activity; aging; anterograde axon cargo transport; auditory receptor cell stereocilium organization and biogenesis; cell aging; cellular iron ion homeostasis; embryo implantation; glutathione metabolic process; heart contraction; hydrogen peroxide biosynthetic process; locomotory behavior; muscle maintenance; myelin maintenance in the peripheral nervous system; myeloid cell homeostasis; negative regulation of apoptosis; negative regulation of cholesterol biosynthetic process; negative regulation of neuron apoptosis; neurofilament cytoskeleton organization and biogenesis; ovarian follicle development; positive regulation of catalytic activity; positive regulation of cytokine production; positive regulation of superoxide release; regulation of blood pressure; regulation of GTPase activity; regulation of mitochondrial membrane potential; regulation of multicellular organism growth; regulation of protein kinase activity; relaxation of vascular smooth muscle; removal of superoxide radicals; response to axon injury; response to copper ion; response to drug; response to ethanol; response to heat; response to hydrogen peroxide; response to nutrient levels; response to organic substance; response to oxidative stress; response to reactive oxygen species; response to superoxide; retinal homeostasis; retrograde axon cargo transport; sensory perception of sound; spermatogenesis; superoxide metabolic process; superoxide release; transmission of nerve impulse

UniProt Code:P08228
NCBI GenInfo Identifier:45597447
NCBI Gene ID:20655
NCBI Accession:NP_035564.1
UniProt Related Accession:P08228
Molecular Weight:17.8 kDa
NCBI Full Name:superoxide dismutase
NCBI Synonym Full Names:superoxide dismutase 1, soluble
NCBI Official Symbol:Sod1  
NCBI Official Synonym Symbols:Ipo1; SODC; Ipo-1; Sod-1; CuZnSOD; Cu/Zn-SOD; B430204E11Rik  
NCBI Protein Information:superoxide dismutase [Cu-Zn]
UniProt Protein Name:Superoxide dismutase [Cu-Zn]
Protein Family:Superoxide dismutase
UniProt Gene Name:Sod1  
UniProt Entry Name:SODC_MOUSE

Related Products