Sod1 Antibody (PACO30068)
- SKU:
- PACO30068
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IP
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Sod1 Antibody (PACO30068)
The SOD1 Antibody (PAC030068) is a valuable tool for researchers studying Superoxide Dismutase 1 (SOD1), an important enzyme involved in antioxidant defense mechanisms. This polyclonal antibody, raised in rabbits, is highly specific to human SOD1 and has been validated for use in Western blot applications. By binding to the SOD1 protein, researchers can accurately detect and analyze its expression in various cell types, making it ideal for investigations in oxidative stress, neurodegenerative diseases, and aging-related research.SOD1 is essential for protecting cells from oxidative damage by converting superoxide radicals into oxygen and hydrogen peroxide.
Dysregulation of SOD1 has been implicated in various diseases, including amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. By studying SOD1 expression and activity, researchers can gain valuable insights into the mechanisms of oxidative stress-related diseases and potentially develop new therapeutic strategies targeting SOD1.Overall, the SOD1 Antibody (PAC030068) is a reliable tool for researchers looking to explore the role of SOD1 in health and disease, providing valuable information for developing potential treatments and interventions in various medical fields.
| Antibody Name: | Sod1 Antibody (PACO30068) |
| Antibody SKU: | PACO30068 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IP |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:10-1:100, IP:1:200-1:2000 |
| Species Reactivity: | Mouse, Rat, Human |
| Immunogen: | Recombinant Mouse Superoxide dismutase [Cu-Zn] protein (2-154AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO30068 at dilution of 1:10. |
 | Western Blot Positive WB detected in: Hela whole cell lysate, 293T whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, Rat brain tissue, Rat liver tissue, Mouse brain tissue All lanes: Sod1 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 16 kDa Observed band size: 16 kDa . |
 | Immunoprecipitating Sod1 in HEK293 whole cell lysate Lane 1: Rabbit control IgG instead of PACO30068 in HEK293 whole cell lysate.For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000) Lane 2: PACO30068 (8µg) + HEK293 whole cell lysate (500µg) Lane 3: HEK293 whole cell lysate (10µg) . |
| Background: | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. |
| Synonyms: | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1), Sod1 |
| UniProt Protein Function: | SOD1: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not. Belongs to the Cu-Zn superoxide dismutase family. |
| UniProt Protein Details: | Protein type:EC 1.15.1.1; Apoptosis; Nuclear receptor co-regulator; Oxidoreductase; Mitochondrial Cellular Component: cell soma; cytoplasm; cytoplasmic vesicle; cytosol; dendrite cytoplasm; extracellular matrix; extracellular region; extracellular space; lysosome; mitochondrial intermembrane space; mitochondrion; myelin sheath; neuron projection; nucleoplasm; nucleus; peroxisome; plasma membrane; protein complex; secretory granule Molecular Function:antioxidant activity; chaperone binding; copper ion binding; enzyme binding; identical protein binding; metal ion binding; oxidoreductase activity; protein binding; protein phosphatase 2B binding; Rac GTPase binding; superoxide dismutase activity; zinc ion binding Biological Process: activation of MAPK activity; aging; anterograde axon cargo transport; auditory receptor cell stereocilium organization and biogenesis; cell aging; cellular iron ion homeostasis; embryo implantation; glutathione metabolic process; heart contraction; hydrogen peroxide biosynthetic process; locomotory behavior; muscle maintenance; myelin maintenance in the peripheral nervous system; myeloid cell homeostasis; negative regulation of apoptosis; negative regulation of cholesterol biosynthetic process; negative regulation of neuron apoptosis; neurofilament cytoskeleton organization and biogenesis; ovarian follicle development; positive regulation of catalytic activity; positive regulation of cytokine production; positive regulation of superoxide release; regulation of blood pressure; regulation of GTPase activity; regulation of mitochondrial membrane potential; regulation of multicellular organism growth; regulation of protein kinase activity; relaxation of vascular smooth muscle; removal of superoxide radicals; response to axon injury; response to copper ion; response to drug; response to ethanol; response to heat; response to hydrogen peroxide; response to nutrient levels; response to organic substance; response to oxidative stress; response to reactive oxygen species; response to superoxide; retinal homeostasis; retrograde axon cargo transport; sensory perception of sound; spermatogenesis; superoxide metabolic process; superoxide release; transmission of nerve impulse |
| UniProt Code: | P08228 |
| NCBI GenInfo Identifier: | 45597447 |
| NCBI Gene ID: | 20655 |
| NCBI Accession: | NP_035564.1 |
| UniProt Related Accession: | P08228 |
| Molecular Weight: | 17.8 kDa |
| NCBI Full Name: | superoxide dismutase |
| NCBI Synonym Full Names: | superoxide dismutase 1, soluble |
| NCBI Official Symbol: | Sod1Â Â |
| NCBI Official Synonym Symbols: | Ipo1; SODC; Ipo-1; Sod-1; CuZnSOD; Cu/Zn-SOD; B430204E11Rik  |
| NCBI Protein Information: | superoxide dismutase [Cu-Zn] |
| UniProt Protein Name: | Superoxide dismutase [Cu-Zn] |
| Protein Family: | Superoxide dismutase |
| UniProt Gene Name: | Sod1Â Â |
| UniProt Entry Name: | SODC_MOUSE |
| ELISA Kits |
| Mouse SOD1 / Superoxide dismutase 1 ELISA Kit |
| Mouse Superoxide dismutase [Cu-Zn] (Sod1) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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