The SOCS6 Polyclonal Antibody (CAB9957) is a valuable tool for researchers studying the suppressor of cytokine signaling 6 (SOCS6) protein, a key regulator of the JAK/STAT signaling pathway. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to SOCS6, researchers can accurately detect and analyze protein expression in a variety of cell types, making it an essential component for studies in immunology and cancer research.
SOCS6, a member of the SOCS family of proteins, plays a crucial role in controlling cytokine signaling and immune responses, making it a promising target for therapeutic interventions in conditions such as cancer, inflammation, and autoimmune diseases. By unraveling the mechanisms by which SOCS6 influences cellular pathways, researchers can identify new strategies for modulating immune responses and potentially developing novel treatment options for a range of diseases.
Product Name:
SOCS6 Rabbit Polyclonal Antibody
SKU:
CAB9957
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human SOCS6 (NP_004223.2).
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
Purification Method:
Affinity purification
Gene ID:
9306
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SOCS6 Rabbit pAb (CAB9957) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
