The SOCS4 Polyclonal Antibody (CAB8003) is a valuable tool for researchers studying the role of SOCS4, a member of the suppressor of cytokine signaling (SOCS) family that plays a crucial role in modulating immune responses. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By binding specifically to SOCS4 protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an essential asset for studies in immunology and cancer research.
SOCS4 acts as a negative regulator of cytokine signaling pathways, thereby influencing immune cell activation and function. Its involvement in immune regulation and potential implications for diseases such as cancer, autoimmunity, and inflammation make it a key target for investigation. By delving into the mechanisms by which SOCS4 modulates immune responses, researchers can uncover insights that may pave the way for the development of novel therapeutic strategies aimed at manipulating immune function in various pathological conditions.
Product Name:
SOCS4 Rabbit Polyclonal Antibody
SKU:
CAB8003
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 340-440 of human SOCS4 (NP_543143.1).
Sequence:
SKVR VLRI DAPE QQC
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
SOCS7; SOCS4
Positive Sample:
K-562,HeLa,NIH/3T3
Conjugate:
Unconjugated
Calculated MW:
51kDa
Observed MW:
51kDa
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
122809
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using SOCS4 Rabbit pAb (CAB8003) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
