The SOCS3 Polyclonal Antibody (CAB0769) is a valuable tool for researchers studying the suppressor of cytokine signaling 3 (SOCS3) protein. SOCS3 is a critical regulator of cytokine signaling pathways, involved in controlling immune responses and inflammation. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for Western blot applications.By specifically binding to the SOCS3 protein, this antibody enables the detection and analysis of SOCS3 levels in various cell types. This makes it ideal for immunology research, as well as studies on inflammatory diseases and cancer.
Understanding the role of SOCS3 in controlling cytokine signaling is essential for developing targeted therapies for conditions such as autoimmune disorders and chronic inflammation.Overall, the SOCS3 Polyclonal Antibody (CAB0769) provides researchers with a reliable tool for investigating the functions of SOCS3 in immune regulation and disease pathogenesis. Its high specificity and sensitivity make it a valuable asset in advancing our understanding of cytokine signaling and its implications in various health conditions.
Product Name:
SOCS3 Rabbit Polyclonal Antibody
SKU:
CAB0769
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 101-225 of human SOCS3 (NP_003946.3).
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
Purification Method:
Affinity purification
Gene ID:
9021
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung using SOCS3 Rabbit pAb(CAB0769) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
