SOCS3 Rabbit Polyclonal Antibody (CAB0694)
- SKU:
- CAB0694
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
Product Name: | SOCS3 Rabbit Polyclonal Antibody |
SKU: | CAB0694 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-225 of human SOCS3 (NP_003946.3). |
Sequence: | MVTH SKFP AAGM SRPL DTSL RLKT FSSK SEYQ LVVN AVRK LQES GFYW SAVT GGEA NLLL SAEP AGTF LIRD SSDQ RHFF TLSV KTQS GTKN LRIQ CEGG SFSL QSDP RSTQ PVPR FDCV LKLV HHYM PPPG APSF PSPP TEPS SEVP EQPS AQPL PGSP PRRA YYIY SGGE KIPL VLSR PLSS NVAT LQHL CRKT VNGH LDSY EKVT QLPG PIRE FLDQ YDAP L |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3; SOCS3 |
Positive Sample: | RAW264.7 |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol |
Calculated MW: | 25kDa |
Observed MW: | 30kDa |
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
Purification Method: | Affinity purification |
Gene ID: | 9021 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |