The SOCS3 Monoclonal Antibody is specifically targeted towards the protein SOCS3, which plays a vital role in the regulation of cytokine signaling and immune response. This monoclonal antibody, produced through advanced technology, is highly specific and sensitive for detecting SOCS3 in various biological samples. SOCS3 is known for its ability to inhibit the JAK/STAT pathway, a key signaling pathway involved in immune response and inflammation. Dysregulation of SOCS3 has been linked to various diseases such as cancer, autoimmune disorders, and inflammatory conditions. By studying the expression and function of SOCS3, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.
This SOCS3 Monoclonal Antibody is ideal for use in immunology and cancer research studies, as it allows for precise detection and analysis of SOCS3 levels in cell lysates, tissues, and other samples. Its high specificity and sensitivity make it a valuable tool for understanding the role of SOCS3 in disease progression and for developing targeted therapies aimed at modulating immune response.
Product Name:
SOCS3 Monoclonal Antibody
SKU:
CAB21981
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 126-225 of human SOCS3 (NP_003946.3).
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
Purification Method:
Affinity purification
Gene ID:
9021
Clone Number:
ARC53312
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SOCS3 antibody (CAB21981) at1:2000 dilution.Raw264.7 cells were treated by LPS (1 μg/ml) at 37℃ for 8 hours.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
