Socs3 Antibody (PACO30064)
- SKU:
- PACO30064
- Product Type:
- Antibody
- Reactivity:
- Rat
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Socs3 Antibody (PACO30064)
The SOCS3 Polyclonal Antibody (PACO30064) is a valuable tool for research involving the SOCS3 protein, a key regulator of cytokine signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to SOCS3, it allows for the accurate detection and analysis of this important protein in various cell types.SOCS3, a member of the suppressor of cytokine signaling (SOCS) protein family, acts as a negative regulator of cytokine signaling by promoting the degradation of signaling proteins.
Its role in modulating immune responses and inflammatory processes makes it a promising target for research in immunology, inflammation, and cancer biology. Understanding the function and regulation of SOCS3 is essential for developing novel therapeutic strategies aimed at modulating cytokine signaling pathways in the context of disease. Overall, the SOCS3 Polyclonal Antibody is a reliable tool for studying the functions and mechanisms of SOCS3, offering researchers the ability to further explore its impact on cellular signaling and disease pathways.
| Antibody Name: | Socs3 Antibody (PACO30064) |
| Antibody SKU: | PACO30064 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000 |
| Species Reactivity: | Rat, Human |
| Immunogen: | Recombinant Rat Suppressor of cytokine signaling 3 protein (1-225AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Socs3 antibody at 12µg/ml Lane 1: K562 whole cell lysate Lane 2: A375 whole cell lysate Lane 3: Hela whole cell lysate Lane 4: HepG2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 25 kDa Observed band size: 25 kDa . |
| Background: | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). |
| Synonyms: | Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3), Socs3, Cish3 |
| UniProt Protein Function: | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST. |
| NCBI Summary: | regulates cytokine levels to modulate inflammation [RGD, Feb 2006] |
| UniProt Code: | O88583 |
| NCBI GenInfo Identifier: | 16758336 |
| NCBI Gene ID: | 89829 |
| NCBI Accession: | NP_446017.1 |
| UniProt Secondary Accession: | O88583,Q9QYV5, |
| UniProt Related Accession: | O88583 |
| Molecular Weight: | 24,808 Da |
| NCBI Full Name: | suppressor of cytokine signaling 3 |
| NCBI Synonym Full Names: | suppressor of cytokine signaling 3 |
| NCBI Official Symbol: | Socs3Â Â |
| NCBI Official Synonym Symbols: | Cish3; Ssi-3; Socs-3Â Â |
| NCBI Protein Information: | suppressor of cytokine signaling 3 |
| UniProt Protein Name: | Suppressor of cytokine signaling 3 |
| UniProt Synonym Protein Names: | Cytokine-inducible SH2 protein 3 |
| Protein Family: | Suppressor of cytokine signaling |
| UniProt Gene Name: | Socs3Â Â |
| UniProt Entry Name: | SOCS3_RAT |
| ELISA Kits |
| Rat SOCS3 / Suppressor of cytokine signaling 3 ELISA Kit |
| Rat SOCS3 (Suppressors Of Cytokine Signaling 3) CLIA Kit (RTES00529) |
| Rat Suppressor of cytokine signaling 3 (Socs3) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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