SOCS2 Rabbit Polyclonal Antibody (CAB17035)
- SKU:
- CAB17035
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
Product Name: | SOCS2 Rabbit Polyclonal Antibody |
SKU: | CAB17035 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human SOCS2 (NP_001257400.1). |
Sequence: | MTLR CLEP SGNG GEGT RSQW GTAG SAEE PSPQ AARL AKAL RELG QTGW YWGS MTVN EAKE KLKE APEG TFLI RDSS HSDY LLTI SVKT SAGP TNLR IEYQ DGKF RLDS IICV KSKL KQFD SVVH LIDY YVQM CKDK RTGP EAPR NGTV HLYL TKPL YTSA PSLQ HLCR LTIN KCTG AIWG LPLP TRLK DYLE EYKF QV |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100 |
Synonyms: | CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2; SOCS2 |
Positive Sample: | A-549,293T |
Cellular Localization: | cytoplasm, cytosol |
Calculated MW: | 22kDa |
Observed MW: | 22kDa |
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 8835 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |