The SOAT1 Polyclonal Antibody (CAB6311) is a valuable tool for researchers studying the role of SOAT1 in lipid metabolism and cholesterol homeostasis. SOAT1, also known as acyl-coenzyme A:cholesterol acyltransferase 1, is an enzyme involved in the esterification of cholesterol in cells. This antibody, raised in rabbits, exhibits high specificity and reactivity to human samples, making it ideal for Western blot applications.SOAT1 plays a crucial role in cholesterol metabolism by converting free cholesterol into cholesterol esters, which are then stored in lipid droplets or incorporated into lipoproteins for transport.
Dysregulation of SOAT1 activity has been linked to various diseases, including atherosclerosis, cardiovascular disorders, and metabolic syndromes.By using the SOAT1 Polyclonal Antibody, researchers can investigate the expression levels and localization of SOAT1 in different cell types and tissues, providing insights into its function and potential therapeutic implications. This antibody is a valuable tool for studies in lipid biology, cardiovascular research, and drug development targeting cholesterol metabolism.
Product Name:
SOAT1 Rabbit Polyclonal Antibody
SKU:
CAB6311
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human SOAT1 (NP_003092.4).
The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6646
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SOAT1 antibody (CAB6311) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
