The SNX33 Polyclonal Antibody (PAC060296) is a valuable tool for researchers studying SNX33, a key protein involved in endosomal sorting and recycling processes within cells. This antibody, produced in rabbits, exhibits high specificity and sensitivity when used in a variety of experimental applications, including Western blotting. By binding to the SNX33 protein, this antibody enables accurate detection and analysis in different cell types, making it an essential asset for investigations in cell biology and endosomal trafficking.SNX33, a member of the sorting nexin protein family, plays a crucial role in directing cargo proteins to their appropriate destinations within the cell and facilitating the recycling of membrane receptors.
Dysregulation of SNX33 function has been linked to various diseases, including neurodegenerative disorders and cancer, highlighting its importance in cellular homeostasis. By studying SNX33 and its interactions, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify targets for therapeutic intervention.
Antibody Name:
SNX33 Antibody (PACO60296)
Antibody SKU:
PACO60296
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:500-1:1000
Species Reactivity:
Human
Immunogen:
Recombinant Human Sorting nexin-33 protein (348-516AA)
IHC image of PACO60296 diluted at 1:800 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.
Synonyms:
Sorting nexin-33 (SH3 and PX domain-containing protein 3), SNX33, SH3PX3 SH3PXD3C SNX30
UniProt Protein Function:
SNX33: Belongs to the sorting nexin family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 15q24.2Cellular Component: cytoplasmic membrane-bound vesicle; cytosol; endosome; extrinsic to membrane; membraneMolecular Function: identical protein binding; phosphoinositide binding; protein bindingBiological Process: cytokinesis after mitosis; endocytosis; endosome organization and biogenesis; endosome transport; negative regulation of endocytosis; positive regulation of membrane protein ectodomain proteolysis; protein import; vesicle organization and biogenesis
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
