SNX33 Antibody (PACO20577)
- SKU:
- PACO20577
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
SNX33 Antibody (PACO20577)
The SNX33 Polyclonal Antibody (PAC020577) is a valuable tool for studying the SNX33 protein, a key regulator of endosomal sorting and membrane trafficking. This antibody, produced in rabbits, exhibits high specificity towards human samples and has been validated for use in Western blot applications. By binding to SNX33, the antibody enables precise detection and analysis of this protein in various cell types, making it an essential asset for researchers in the fields of cell biology and intracellular transport.SNX33 is a crucial player in the process of endosomal sorting, influencing the recycling and degradation of cell surface receptors and other membrane proteins.
Its involvement in these cellular processes makes it an attractive target for investigations into diseases related to abnormal protein trafficking, such as neurodegenerative disorders and certain types of cancer. By delving into the functions of SNX33, researchers can gain insights that may lead to the development of novel therapeutic strategies targeting these conditions.
| Antibody Name: | SNX33 Antibody (PACO20577) |
| Antibody SKU: | PACO20577 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human SNX33 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO20577(SNX33 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO20577(SNX33 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | SNX33 (sorting nexin-33), also known as SH3PX3, SH3PXD3C or SNX30, is a 574 amino acid, protein that interacts with ADAM15 and FAS-L. Belonging to the sorting nexin family, SNX33 contains one BAR domain, one PX (phox homology) domain and one SH3 domain. The gene that encodes SNX33 consists of over 14,000 bases and maps to human chromosome 15q24.2. Housing approximately 106 million base pairs and encoding more than 700 genes, chromosome 15 makes up about 3% of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. |
| Synonyms: | sorting nexin 33 |
| UniProt Protein Function: | SNX33: Belongs to the sorting nexin family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 15q24.2Cellular Component: cytoplasmic membrane-bound vesicle; cytosol; endosome; extrinsic to membrane; membraneMolecular Function: identical protein binding; phosphoinositide binding; protein bindingBiological Process: cytokinesis after mitosis; endocytosis; endosome organization and biogenesis; endosome transport; negative regulation of endocytosis; positive regulation of membrane protein ectodomain proteolysis; protein import; vesicle organization and biogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q8WV41 |
| NCBI GenInfo Identifier: | 74751538 |
| NCBI Gene ID: | 257364 |
| NCBI Accession: | Q8WV41.1 |
| UniProt Secondary Accession: | Q8WV41,B1NM17 |
| UniProt Related Accession: | Q8WV41 |
| Molecular Weight: | 65,265 Da |
| NCBI Full Name: | Sorting nexin-33 |
| NCBI Synonym Full Names: | sorting nexin 33 |
| NCBI Official Symbol: | SNX33Â Â |
| NCBI Official Synonym Symbols: | SNX30; SH3PX3; SH3PXD3CÂ Â |
| NCBI Protein Information: | sorting nexin-33 |
| UniProt Protein Name: | Sorting nexin-33 |
| UniProt Synonym Protein Names: | SH3 and PX domain-containing protein 3 |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX33Â Â |
| UniProt Entry Name: | SNX33_HUMAN |
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