SNX27 Antibody (PACO50854)
- SKU:
- PACO50854
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SNX27 Antibody (PACO50854)
The SNX27 Polyclonal Antibody (PAC050854) is a valuable tool for researchers studying SNX27, a critical protein involved in endosomal trafficking and recycling. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards SNX27 in human samples, making it a reliable choice for Western blot applications. By binding to SNX27, this antibody allows for the detection and analysis of this protein in a variety of cell types, making it an essential reagent for studies in cell biology and membrane trafficking.SNX27 is an essential component of the endosomal sorting machinery, playing a key role in the recycling of cell surface receptors and maintaining cellular homeostasis.
Its involvement in signaling pathways and protein trafficking makes it a promising target for research in various fields, including neurobiology, cancer biology, and cell physiology. By investigating the functions of SNX27, researchers can gain insights into cellular processes and potentially identify novel therapeutic targets for diseases associated with membrane trafficking defects.
| Antibody Name: | SNX27 Antibody (PACO50854) |
| Antibody SKU: | PACO50854 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Sorting nexin-27 protein (458-497AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate. All lanes: SNX27 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 62, 60, 51 kDa. Observed band size: 51 kDa.. |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO50854 at dilution of 1:100. |
| Background: | Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. |
| Synonyms: | Sorting nexin-27, SNX27, KIAA0488 |
| UniProt Protein Function: | SNX27: Involved in endocytic trafficking. In T lymphocytes, participates in endocytic recycling pathway. Recruits PSCDBP and HT4R to early endosomes. Belongs to the sorting nexin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: cytoplasm; early endosome; immunological synapse; nucleoplasm; retromer complex Molecular Function:phosphatidylinositol 3-phosphate binding; protein binding Biological Process: endosome transport; establishment of natural killer cell polarity; intracellular protein transport |
| NCBI Summary: | This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96L92 |
| NCBI GenInfo Identifier: | 166214988 |
| NCBI Gene ID: | 81609 |
| NCBI Accession: | Q96L92.2 |
| UniProt Secondary Accession: | Q96L92,Q32Q36, Q4AEJ5, Q5VWB0, Q5VWB1, Q5VWB2, Q6IPP6 Q86UB1, Q96D79, Q9H3K8, |
| UniProt Related Accession: | Q96L92 |
| Molecular Weight: | 27,781 Da |
| NCBI Full Name: | Sorting nexin-27 |
| NCBI Synonym Full Names: | sorting nexin family member 27 |
| NCBI Official Symbol: | SNX27Â Â |
| NCBI Official Synonym Symbols: | MRT1; MY014Â Â |
| NCBI Protein Information: | sorting nexin-27 |
| UniProt Protein Name: | Sorting nexin-27 |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX27Â Â |
| UniProt Entry Name: | SNX27_HUMAN |
| Antibodies |
| SNX27 Antibody (PACO12382) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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