The SNX20 Polyclonal Antibody (PAC017140) is a crucial tool for researchers studying the cellular protein SNX20, which is involved in intracellular protein trafficking and sorting. This antibody, generated in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to SNX20, this antibody allows for the detection and analysis of the protein in various cell types, making it an essential tool for studies in cell biology and molecular biology.
SNX20 is a key player in the endosomal sorting pathway, regulating the transport of proteins within the cell and impacting cell signaling processes. Dysfunction of SNX20 has been implicated in various diseases such as neurodegenerative disorders, cancer, and metabolic syndromes. By studying the function and regulation of SNX20, researchers can gain valuable insights into cellular processes and potentially develop novel therapeutic strategies for treating these diseases.
Antibody Name:
SNX20 Antibody (PACO17140)
Antibody SKU:
PACO17140
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Fusion protein of human SNX20
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17140(SNX20 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
SNX20 interacts with the cytoplasmic domain of PSGL1 (SELPLG; MIM 600738) and cycles PSGL1 into endosomes.
Synonyms:
sorting nexin 20
UniProt Protein Function:
SNX20: Serves as a sorting protein that cycles P-selectin glycoprotein ligand 1 (PSLG1) into endosomes with no impact on leukocytes recruitment. Belongs to the sorting nexin family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Lipid-bindingChromosomal Location of Human Ortholog: 16q12.1Cellular Component: plasma membrane; endosome membrane; nucleusMolecular Function: protein binding; phosphoinositide bindingBiological Process: protein transport
UniProt Protein Details:
NCBI Summary:
SNX20 interacts with the cytoplasmic domain of PSGL1 (SELPLG; MIM 600738) and cycles PSGL1 into endosomes.[supplied by OMIM, Feb 2010]
