The SNX15 Polyclonal Antibody (CAB9158) is a valuable tool for researchers studying SNX15, a sorting nexin protein involved in intracellular trafficking and signaling pathways. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for use in various research applications such as Western blotting.SNX15 is implicated in endosomal sorting and recycling processes, playing a key role in maintaining cellular homeostasis and regulating cellular signaling pathways. Dysfunction of SNX15 has been linked to various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions.
By using the SNX15 Polyclonal Antibody, researchers can accurately detect and analyze SNX15 expression in different cell types, providing valuable insights into its function and potential role in disease pathology. This antibody is a valuable tool for studies in cell biology, molecular biology, and drug development, offering a deeper understanding of SNX15 biology and its implications in human health and disease.
Product Name:
SNX15 Rabbit Polyclonal Antibody
SKU:
CAB9158
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-342 of human SNX15 (NP_037438.2).
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene.
Purification Method:
Affinity purification
Gene ID:
29907
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SNX15 Rabbit pAb (CAB9158) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
