SNX14 Antibody (PACO46762)
- SKU:
- PACO46762
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | SNX14 Antibody (PACO46762) |
| Antibody SKU: | PACO46762 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Sorting nexin-14 protein (601-893AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO46762 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO46762 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO46762 at dilution of 1:100. |
| Background: | Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)). |
| Synonyms: | Sorting nexin-14, SNX14 |
| UniProt Protein Function: | SNX14: May be involved in several stages of intracellular trafficking. Belongs to the sorting nexin family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 6q14.3Cellular Component: late endosome; lysosomeDisease: Spinocerebellar Ataxia, Autosomal Recessive 20 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the sorting nexin family. Members of this family have a phox (PX) phosphoinositide binding domain and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Alternate splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q9Y5W7 |
| NCBI GenInfo Identifier: | 254763401 |
| NCBI Gene ID: | 57231 |
| NCBI Accession: | Q9Y5W7.3 |
| UniProt Secondary Accession: | Q9Y5W7,Q4VBR3, Q5TCF9, Q5TCG0, Q6NUI7, Q6PI37, Q9BSD1 B4DI55 |
| UniProt Related Accession: | Q9Y5W7 |
| Molecular Weight: | 109,191 Da |
| NCBI Full Name: | Sorting nexin-14 |
| NCBI Synonym Full Names: | sorting nexin 14 |
| NCBI Official Symbol: | SNX14Â Â |
| NCBI Official Synonym Symbols: | SCAR20; RGS-PX2Â Â |
| NCBI Protein Information: | sorting nexin-14 |
| UniProt Protein Name: | Sorting nexin-14 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX14Â Â |
| UniProt Entry Name: | SNX14_HUMAN |