The SNX14 Polyclonal Antibody (PAC046762) is a valuable tool for researchers studying SNX14, a crucial protein involved in endosomal sorting and trafficking processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it an ideal choice for Western blotting and immunofluorescence applications.SNX14 is a key player in the regulation of endosomal trafficking pathways, impacting various cellular processes such as receptor recycling and lysosomal degradation. Dysregulation of SNX14 has been implicated in diseases like cancer, neurodegenerative disorders, and lysosomal storage diseases, making it a promising target for therapeutic intervention.
By utilizing the SNX14 Polyclonal Antibody, researchers can investigate the role of SNX14 in cellular homeostasis and disease pathogenesis, paving the way for the development of novel treatments and interventions targeting endosomal trafficking pathways. Get your hands on this high-quality antibody today and advance your research in cell biology and disease mechanisms.
Immunohistochemistry of paraffin-embedded human liver tissue using PACO46762 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO46762 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO46762 at dilution of 1:100.
Background:
Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)).
Synonyms:
Sorting nexin-14, SNX14
UniProt Protein Function:
SNX14: May be involved in several stages of intracellular trafficking. Belongs to the sorting nexin family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 6q14.3Cellular Component: late endosome; lysosomeDisease: Spinocerebellar Ataxia, Autosomal Recessive 20
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the sorting nexin family. Members of this family have a phox (PX) phosphoinositide binding domain and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Alternate splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
