The SNX13 Polyclonal Antibody (CAB12821) is a valuable tool for researchers studying SNX13, a protein involved in intracellular trafficking and membrane dynamics. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to SNX13, this antibody allows for the detection and analysis of this protein in a variety of cell types, making it ideal for investigations in cell biology and molecular biology.SNX13 is known to play a critical role in various cellular processes, including endosomal sorting and recycling pathways. Its involvement in membrane trafficking suggests its potential significance in diseases related to cellular dysfunction, such as neurodegenerative disorders and metabolic diseases.
Research on SNX13 may provide insights into the underlying mechanisms of these conditions and pave the way for the development of novel therapeutic interventions targeting intracellular trafficking pathways.Overall, the SNX13 Polyclonal Antibody offers researchers a reliable tool for studying the function and regulation of SNX13 in cellular processes, with potential implications for understanding and treating a range of diseases.
Product Name:
SNX13 Rabbit Polyclonal Antibody
SKU:
CAB12821
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-230 of human SNX13 (NP_055947.1).
Cytoplasmic side, Early endosome membrane, Peripheral membrane protein.
Calculated MW:
112kDa
Observed MW:
112kDa
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.
Purification Method:
Affinity purification
Gene ID:
23161
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SNX13 Rabbit pAb (CAB12821) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
