The SNX12 Polyclonal Antibody (PAC017137) is a valuable tool for researchers studying SNX12, a key component of the sorting nexin family involved in endosomal recycling and protein trafficking. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.SNX12 plays a crucial role in the sorting and recycling of proteins within the endosomal pathway, contributing to cellular processes such as receptor signaling and lipid metabolism. By targeting SNX12 with this antibody, researchers can detect and analyze the protein in various cell types, providing insight into its function and potential implications in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes.
Understanding the role of SNX12 in intracellular trafficking and protein sorting is essential for unraveling the mechanisms underlying cellular homeostasis and disease pathogenesis. The SNX12 Polyclonal Antibody offers a reliable tool for investigating the functions of SNX12, aiding in the development of targeted therapies and diagnostic strategies for a wide range of cellular and metabolic disorders.
Antibody Name:
SNX12 Antibody (PACO17137)
Antibody SKU:
PACO17137
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human SNX12
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 12%SDS-PAGE, Lysate: 80 μg, Lane: Mouse bladder tissue, Primary antibody: PACO17137(SNX12 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
Background:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. A similar protein in mouse may be involved in regulating the neurite outgrowth. Alternate splicing results in multiple transcript variants.
Synonyms:
sorting nexin 12
UniProt Protein Function:
May be involved in several stages of intracellular trafficking.
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. A similar protein in mouse may be involved in regulating the neurite outgrowth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
