The SNRPN Polyclonal Antibody (CAB15726) is a valuable tool for researchers studying SNRPN, a gene associated with Prader-Willi Syndrome and Angelman Syndrome. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the SNRPN protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for investigations in developmental biology and genetic disorders.
SNRPN plays a crucial role in the regulation of gene expression and neurodevelopment, making it a key target for studies on the molecular mechanisms underlying Prader-Willi Syndrome and Angelman Syndrome. Understanding the function of SNRPN is essential for developing potential therapeutic interventions for these genetic disorders. Researchers can utilize the SNRPN Polyclonal Antibody to further unravel the complexities of SNRPN biology and its implications in human health.
Product Name:
SNRPN Rabbit Polyclonal Antibody
SKU:
CAB15726
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SNRPN (NP_003088.1).
This gene is located within the Prader-Willi Syndrome critical region on chromosome 15 and is imprinted and expressed from the paternal allele. It encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing and may contribute to tissue-specific alternative splicing. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants that initiate at the CpG island-associated imprinting center may be bicistronic and also encode the SNRPN upstream reading frame protein (SNURF) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (SNHG14) may originate from the promoters at this locus and share exons with this gene. Alterations in this region are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome.
Purification Method:
Affinity purification
Gene ID:
6638
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SNRPN Rabbit pAb (CAB15726) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
