The SNRPE Polyclonal Antibody (CAB5488) is a valuable tool for researchers studying SNRPE, a key component of the small nuclear ribonucleoprotein complex essential for pre-mRNA splicing. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.SNRPE, also known as small nuclear ribonucleoprotein polypeptide E, plays a crucial role in the splicing process by facilitating the assembly of spliceosomal complexes. Dysregulation of SNRPE has been implicated in various diseases, including cancer and genetic disorders. By targeting SNRPE with this polyclonal antibody, researchers can analyze its expression levels and subcellular localization in different cell types, shedding light on its functional roles in splicing mechanisms.
The ability to detect and study SNRPE using this polyclonal antibody makes it an invaluable resource for investigating the molecular mechanisms underlying pre-mRNA splicing and its implications in disease pathology. Researchers in the fields of molecular biology, genetics, and cancer biology will find this antibody essential for their studies on RNA processing and gene expression regulation.
Product Name:
SNRPE Rabbit Polyclonal Antibody
SKU:
CAB5488
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-92 of human SNRPE (NP_003085.1).
The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis. Several pseudogenes of this gene have been identified.
Purification Method:
Affinity purification
Gene ID:
6635
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using SNRPE Rabbit pAb (CAB5488) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
