The SNRPA Polyclonal Antibody (CAB6410) is a valuable tool for researchers studying SNRPA, a essential component of the spliceosome complex involved in pre-mRNA splicing. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to the SNRPA protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in molecular biology and genetics.
SNRPA, also known as U1A, plays a crucial role in the processing of precursor messenger RNA by recognizing and binding to specific RNA sequences. Dysregulation of SNRPA has been linked to various diseases, including autoimmune disorders and cancer, highlighting its importance in cellular processes. Research into the function of SNRPA is essential for gaining insights into disease mechanisms and developing potential therapeutic interventions targeting RNA splicing.
Product Name:
U1A/SNRPA Rabbit Polyclonal Antibody
SKU:
CAB6410
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-282 of human U1A/U1A/SNRPA (NP_004587.1).
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation.
Purification Method:
Affinity purification
Gene ID:
6626
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using U1A/SNRPA Rabbit pAb (CAB6410) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
