The SNRNP200 Polyclonal Antibody (CAB6063) is a vital tool for researchers studying SNRNP200, a key protein involved in RNA splicing and processing. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it an ideal choice for Western blot experiments. By binding to SNRNP200, this antibody enables researchers to accurately detect and analyze the protein in various cell types, facilitating investigations into RNA metabolism and gene expression regulation.SNRNP200 is a crucial component of the spliceosome complex, responsible for removing introns from pre-mRNA molecules during gene expression. Dysregulation of SNRNP200 has been linked to various diseases, including spinal muscular atrophy and cancer.
By studying the function and expression of SNRNP200, researchers can gain valuable insights into the mechanisms underlying these conditions, paving the way for the development of novel therapeutic strategies.Overall, the SNRNP200 Polyclonal Antibody (CAB6063) is an essential tool for scientists seeking to unravel the complexities of RNA splicing and its role in health and disease. Its high specificity and reactivity make it a reliable choice for research in molecular biology, genetics, and oncology, driving advancements in our understanding of gene regulation and potential targets for therapeutic intervention.
Product Name:
SNRNP200 Rabbit Polyclonal Antibody
SKU:
CAB6063
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1947-2136 of human SNRNP200 (NP_054733.2).
Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative RNA helicases. It is a core component of U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Mutations in this gene cause autosomal-dominant retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
23020
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SNRNP200 Rabbit pAb (CAB6063) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
